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highlighted the importance of using different 3D culture systems with the relevant tissue architecture and phenotype as well as normal tissues and how the establishment of a collaborative online database linked to distinct cell banks would catalyze preclinical MB research ( MYC amplification exhibit invasive growth patterns depending on the 3D extracellular matrix (ECM) (such as collagen) and that venetoclax (a BCL-2 inhibitor) synergizes with chemotherapy, overcoming apoptosis resistance ( MYC -dependent metabolic vulnerabilities in Group 3, including sensitivity to glutaminase inhibitors ( Figure 1 )

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Gut 61 , 1146–1153 (2012)